The Effect of Esmolol on Clinical Prognosis of Patients With Severe Sepsis

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to investigate the effect of esmolol on hemodynamic parameters,tissue perfusion and the clinical prognosis of patients with severe sepsis

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fujian Provincial Hospital
• Treatments: Esmolol

Criteria

Inclusion Criteria:

• age > 18 years;

• severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock,

• mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg;

• satisfactory sedation and analgesic treatment, with HR > 100 bpm.

Exclusion Criteria:

• pre-existing cardiac dysfunction, valvular heart disease, high-degree atrioventricular block;

• acute or chronic pulmonary heart disease;

• a history of serious asthma;

• chronic renal insufficiency;

• cancer, autoimmune diseases, or contraindications for placement of deep venous catheter;

• insulin-dependent diabetes.