The Effect of Fasudil on Vascular Function in Humans

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Fasudil

Criteria

Inclusion Criteria:

• Coronary artery disease

• Hyperlipidemia -OR-

• Healthy adults

Exclusion Criteria:

• Unstable angina, myocardial infarction or revascularization within 3 months

• Symptomatic heart failure

• Creatinine > 3.0 mg/dl

• Liver enzymes > 3X upper limit of normal

• Chronic hypoxia

• Significant anemia

• Chronic inflammatory disease

• Pregnancy

• Willing to withdraw statins for duration of study