The Effect of GIP, GLP-1 and GLP-2 in Individuals With Genetically Altered Receptor Function

• Status: Recruiting
• Trial end date: 2027-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This project will characterize the physiological effect of the hormones, GIP-, GLP-1- and GLP-2 infusions in a group of individuals that are carriers of GIP-, GLP-1- and GLP-2 receptor gene variants, respectively.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Collaborator: Gentofte Hospital, Denmark

Criteria

Inclusion Criteria:

• BMI 19-35 kg/m2

Exclusion Criteria:

• Treatment with medication or supplements that can not be discontinued for 12 hours

• >10 objects of alcohol weekly or abuse of narcotics

• Liver disease (defined as ALAT and/or ASAT ≥ 2 x normal levels)

• Decreased kidney function (creatine levels over reference interval)

• Uncontrollable increased blood pressure (> 140/90 mmHg)

• Low blood percentage (hemoglobin < 8.3 mmol/l)

• Special diet or planned weight change during trial period

• Other conditions that could be expected to affect the primary or secondary outcomes