The Effect of Gabapentin, Ketamine and Dexamethasone on Pain and Opioid Requirements After Hip Surgery

• Status: Terminated
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients scheduled for primary hip replacement needs postoperative pain treatment, i.e. morphine. Morphine has side-effects: nausea, vomiting, sedation and dizziness. These side-effects are unpleasant for the patients and sometimes keeps them at bed longer time than needed. We investigate in new combinations of analgesics for postoperative pain, hoping to minimize the need for morphine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Glostrup University Hospital, Copenhagen
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Gabapentin; gamma-Aminobutyric Acid; Ketamine

Criteria

Inclusion Criteria:

• Patients scheduled for primary total hip replacement,

• Between 55 and 85 years of age,

• ASA 1-3 and BMI between 18 and 35.

Exclusion Criteria:

Patients who are:

• Unable to cooperate

• Does not speak Danish

• Has allergy for drugs used in the trial

• Drug or alcohol abuse

• Epilepsy

• Medically treated diabetes

• Known kidney disease

• Daily use of analgetics

• Apart from NSAID

• Paracetamol or COX2 inhibitors

• Are treated with a antidepressive.