The Effect of Gastric Emptying on Blood Glucose Profile of Type 1 Diabetes Mellitus and Its Therapeutic Strategies

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Establish a cohort study to describe the characteristics of gastric emptying in patients with type 1 diabetes, and adjust the timing of insulin injection during meals to improve blood glucose fluctuations according to the speed of gastric emptying.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nanjing First Hospital, Nanjing Medical University
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• 1.Volunteer and sign subject informed consent prior to the trial.

2.Patients with type 1 diabetes, aged less than 70 years, 7%≤HbA1c≤9.0%.

3.There were no acute complications such as diabetic ketoacidosis and diabetic hypertonic syndrome.

4.Subjects were able and willing to undergo 14-day scanning blood glucose monitoring, diet and exercise routine.

Exclusion Criteria:

• 1.Patients with severe gastrointestinal symptoms, history of gastrointestinal disease, surgical history, or impaired liver and kidney function.

2.Patients who have used drugs that affect gastrointestinal function or appetite in the last week.

3.History of drug abuse and alcohol dependence within the past 5 years.

4.Systemic hormone therapy was used in the last three months.

5.Patients with poor compliance, irregular diet and exercise.

6.Patients with infection and stress within four weeks.

7.Patients who could not tolerate 14-day scanning blood glucose monitoring.

8.Patients who are pregnant, nursing or intending to become pregnant.

9.Any other obvious condition or comorbidities determined by the investigator: such as serious cardiopulmonary disease, endocrine disease, neurological, neoplastic, other pancreatic disease, history of mental illness.