The Effect of Gender on Antidiuresis - Evaluated by Graded Low Dose Desmopressin Infusion
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
There is substantial evidence that women throughout life have significantly lower plasma
levels of the antidiuretic hormone vasopressin (pAVP) compared to men. The importance of this
is not yet fully elucidated, but in relation to the observations of lower pAVP levels, no
significant difference in renal response parameters was found. This could be interpreted an
increased renal sensitivity in females compared to males. The theory of increased renal
sensitivity in females is supported by a few pharmacodynamic studies currently available on
this topic. However none of the studies was designed with the purpose of investigate the
gender difference.
The aim of this study is to investigate possible gender differences in the renal sensitivity
to dDAVP and the effect of age on these differences. This will be done by low dose graded
infusion of the synthetic AVP analog dDAVP.
Participants are 80 healthy volunteers equally distributed between four age groups, 8-10
years of age, 16-18 years of age, 25-40 years og age and 65+ years of age.