The Effect of General Anesthesia on Pharmacokinetics of Oxycodone in Pediatric
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Oxycodone is an oral opioid analgesic that is most commonly prescribed for the management of
pain in post-operative patients at Boston Children's Hospital. Oxycodone has been widely used
in adults and children to relieve post-operative pain. However, its pharmacokinetics (what it
does in the body) and pharmacodynamics (how it works) have not been well established in
children. Some children, because of their specific genetic make-up, may metabolize the drug
more quickly and therefore may be at risk for more side effects in the commonly prescribed
dose. The investigators would like to find out more about how general anesthesia (GA) effects
how this drug is absorbed, metabolized and excreted in children. In order to study these
aspects, the investigators would like to give oxycodone to surgical patients (group one will
receive oxycodone at the beginning of GA and group two will receive oxycodone at the end of
GA) at Boston Children's Hospital then measure its metabolic activity and also perform a
specific genetic analysis.
Phase:
Phase 4
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital