The Effect of Glutamatergic Modulation on Cocaine Self-administration
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
Repeated drug consumption may progress to problematic use by triggering neuroplastic
adaptations that attenuate sensitivity to natural rewards while increasing reactivity to
craving and drug cues. Converging evidence suggests that glutamate modulation may work to
correct these adaptations and rapidly restore motivation for delayed non-drug rewards
relative to immediate drug use. Using an established laboratory model aimed at evaluating
behavioral shifts in the salience of cocaine now vs. money later, the investigators will test
the effect of CI-581a on cocaine self-administration as compared to the active control.