The Effect of Gut Sterilisation on Macrophage Activation in Patients With Alcoholic Hepatitis.

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Alcoholic hepatitis (AH) is a severe alcohol induced hepatic inflammation that leads to jaundice and liver failure. Gut derived bacterial translocation to the liver is currently thought to be one of the main inflammatory drivers of the disease.

This project investigates the effects of gut sterilisation with broad spectrum antibiotics in patients with AH

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Treatments: Disinfectants; Gentamicins; Meropenem; Vancomycin

Criteria

Inclusion Criteria:

A first time diagnose of AH by a combination of physical and laboratory criteria:

1. A history of excessive alcohol ingestion (10 units or more per day) until at least three weeks before admission

2. Acute jaundice (developed over at most 2 weeks, serum bilirubin > 80 μmol/l).

3. liverbiopsy will be performed in case of doubt regarding the diagnosis.

Exclusion Criteria:

1. Non-native speaking Danish

2. Viral hepatitis,

3. Autoimmune liver disease,

4. Bile duct obstruction,

5. Liver tumours or any other cancer,

6. Presence of an infectious focus (either clinically assessed or based on chest x-ray, urine samples or ascites puncture),

7. On-going gastrointestinal bleeding or bleeding within the previous three months

8. Any prior immune-modulating therapy.

9. Any known gastrointestinal disease

10. Contraindications against/allergy towards the used antibiotics