The Effect of H. Pylori Infection on Iron Metabolism

• Status: Completed
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if Helicobacter pylori (H. pylori) gastritis results in abnormal iron metabolism in patients with iron deficiency anemia (IDA), and to determine if this is due to strain variations in the H. pylori organism.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seattle Institute for Biomedical and Clinical Research
• Collaborators: Eisai Inc.; PriCara, Unit of Ortho-McNeil, Inc.

Criteria

Inclusion Criteria:

• age > 18 years

• iron deficiency anemia (IDA) defined as: Hgb < 14 g/L for men and 12 g/L for women, and a serum ferritin level less than 45 ug/L

Exclusion Criteria:

• Obvious non-GI cause of blood loss

• Chronic renal failure (BUN>60, Creatinine > 4)

• Hemolytic anemia, thalassemia, aplastic anemia

• Known alcoholism or cirrhosis of the liver

• Regular use (>3x weekly) of NSAIDS

• Prior gastric resection

• Celiac disease

• Known GI or hematologic malignancy

• Known inflammatory bowel disease