The Effect of Heparin on Inhalation Injury

• Status: Withdrawn
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a prospective randomized clinical trial about the efficacy of heparin nebulization on lung injury score in inhalation burn injury in Mothary burn hospital. This study would consist of 170 burn patients with documented inhalation injury in 2 arms (control group and study group). Allocation ratio is1:1. Masking was not possible. The patients' primary outcome will be assessed for Lung Injury Scale and the patients' secondary outcome will be assessed for mortality, Coagulation tests (PT, PTT), ICU and hospital stay and duration of mechanical ventilation support. Duration of this study is about 32 months.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tehran University of Medical Sciences
• Treatments: Calcium heparin; Heparin

Criteria

Inclusion Criteria:

• Burn patients admitted to Motahary burn center with documented inhalation injury (as defined by clinical or bronchoscopic evaluation)

Exclusion Criteria:

• Non-survivable burn patients;

• history of coagulation disease;

• chronic obstructive pulmonary disease(COPD);

• pneumonia diagnosed at admission;

• inability to confirm definitive diagnosis of inhalation injury and co poisoning or Cyanide hydrogen intoxication