Overview

The Effect of Hepatic Vein Pressure Gradient(HVPG)-Guided Therapy in Cirrhotic Patients With Esophagogastric Varices

Status:
Unknown status
Trial end date:
2018-09-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of the study is to compare the effect of HVPG-guided individualized therapy and non-HVPG guided traditional therapy in cirrhotic patients for secondary prophylaxis.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Shanghai Zhongshan Hospital
Collaborators:
Eastern Hepatobiliary Surgery Hospital
Gongli Hospital of Shanghai Pudong District
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai Public Health Clinical Center
Shanghai Pudong New Area Gongli Hospital
ShuGuang Hospital
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Treatments:
Carvedilol
Criteria
Inclusion Criteria:

- Patients with cirrhosis diagnosed by histology, radiological evidence of cirrhosis,
and endoscopic evidence of varices;

- Patients with a previous history of variceal hemorrhage;

- Patients admitted to Zhongshan Hospital and other 6 tertiary centers in Shanghai from
Dec 1, 2015 to Sep 31,2018

Exclusion Criteria:

- Patients already taken secondary prophylactic treatment including endoscopic,
pharmacological, surgical and interventional therapies;

- Patients with severe systemic diseases such as chronic heart failure or chronic renal
failure that will have impact on survival;

- Patients in pregnancy and lactation;

- Patients already diagnosed with hepatic cellular carcinoma or other malignant tumors;

- Patients with contraindication to treatment of endoscopy, surgery and TIPS: severe
coagulation defects, allergic to contrast medium used in TIPS, hepatic encephalopathy,
spontaneous bacterial peritonitis;

- Patients with conditions that will influence the accuracy of HVPG measurement:
Cavernous transformation of portal vein, diffused portal vein thrombosis, severe
shunt;

- Patients refuse to give consent to the study.