The Effect of High Dose Simvastatine on Multiple Myeloma

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the effect of high doses of Simvastatine on bone metabolisme and biochemical markers of disease in Multiple Myeloma

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vejle Hospital
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• multiple myeloma-patients in need of treatment

• stable og progressive disease

• age = or > 18 years

• performance status < 3

• life expectancy > 3 months

Exclusion Criteria:

• pregnancy

• patients incapable of giving personally concent

• renal insufficiens with creatinine clearance below 25 ml/min

• alanin aminotransferasis > 2,5 x upper reference limit

• thyroxine below lower reference limit

• known familiar muscle-disease ar previous myopati

• creatinine kinase > 10 x upper reference limit

• medication with drugs with known interactions wiht simvastatine