The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will evaluate the efficacy of high dose vitamin C in chronic hepatitis patients whose serum liver enzymes are elevated more than upper limit.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Ascorbic Acid; Vitamins

Criteria

Inclusion Criteria:

1. Chronic hepatitis C patients

• positive anti-HCV antibody more than 6 months

• serum alanine aminotransferase 40 - 80 IU/L for more than 6 months

• not indicated for antiviral therapy with interferon and ribavirin

2. Chronic alcoholic hepatitis

• significant alcohol drinking history and no other cause of chronic hepatitis

• serum alanine aminotransferase 40 - 80 IU/L for more than 6 months

Exclusion Criteria:

• Chronic hepatitis B, autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease, hemochromatosis, other chronic hepatitis except chronic hepatitis C or alcoholic hepatitis

• decompensated liver cirrhosis

• platelet < 50,000/uL or white blood cell < 1,500/uL

• need and willing for antiviral therapy

• significant renal dysfunction (GFR < 30 mL/min/kg) or history of renal stone

• hepatotonic drug (i.e. silymarin, garlic oil, aronamin gold) usage within 2 weeks

• pregnancy, lactating woman