The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)

• Status: Completed
• Trial end date: 2010-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study will evaluate the effect of Aliskiren and Losartan on renal blood flow using PAH clearance, PC MRA and ASL MRI methodologies.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Losartan

Criteria

Inclusion Criteria:

• Subject is in generally good health

• Subject is willing to avoid unaccustomed strenuous exercise during the study

• Subject agrees to consume ONLY the study-specified diet during all domiciled periods

• Subject has been a non-smoker for at least 3 months prior to study

• Subject will refrain from smoking or using any tobacco products during the study

• Subject agrees to refrain from consuming alcohol or caffeine during the domiciled periods and agrees to limit alcohol and caffeine consumption throughout the study

Exclusion Criteria:

• Subject has contraindication to MRI scans

• Subject has a history of stroke, seizure, or major neurological disorders

• Subject uses illicit drugs or has a history of drug/alcohol abuse

• Subject has had major surgery, has donated or lost 1 unit of blood, or has been in another investigational study in the last 4 weeks

• Subject has a history of multiple and/or severe allergies to drugs or food