The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy

• Status: Completed
• Trial end date: 2018-06-20
• Target enrollment: 0
• Participant gender: Female

Summary

To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Michigan
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Antepartum women

• Diagnosis of Gestational Hypertension or Pre-eclampsia by blood pressure ≥140 systolic or ≥90 diastolic, on at least 2 measurements ≥ 4 hours apart; with or without proteinuria (urine protein-creatinine ratio ≥0.3 or 24 hour-urine protein ≥300 mg).

• Taking one or fewer oral medications for blood pressure control.

• Singleton gestation.

• English-speaking

Exclusion Criteria:

• Allergy to nonsteroidal anti-inflammatory drugs, aspirin, or acetaminophen

• More than 1 severe range blood pressure (≥160 systolic or ≥110 diastolic) prior to enrollment.

• Neurologic symptoms attributed to hypertension (headache, visual changes) prior to enrollment.

• Pulmonary edema.

• Elevated AST (>60 international units/L) or ALT (>70 international units/L) prior to enrollment.

• Low platelet count (<100,000/microliter) prior to enrollment.

• Renal insufficiency (creatinine > 1.1 or double the baseline creatinine if known) prior to enrollment.

• Chronic hypertension defined as hypertension pre-existing pregnancy or diagnosed prior to 20-weeks' gestation.

• Moderate- or severe-persistent asthma.

• Therapeutic anticoagulation.

• Chronic opiate use during the pregnancy (opiate therapy given daily for > 2 weeks).

• Lactose intolerance or allergy due to placebo containing lactose.

• Cesarean delivery.

• Additional anesthesia at time of delivery (spinal anesthesia, sedation) that would change routine pain management.