The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

• Status: Completed
• Trial end date: 2018-10-24
• Target enrollment: 0
• Participant gender: All

Summary

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul St. Mary's Hospital
• Collaborator: The Catholic University of Korea
• Treatments: Iloprost

Criteria

Inclusion Criteria:

• elective video-assisted thoracoscopic surgery (VATS) lobectomy

• 20 < age < 75

• American Society of Anesthesiologists (ASA) classification I~III

Exclusion Criteria:

• ASA classification IV

• New York Heart Association (NYHA) class III~IV

• Severe obstructive lung disease / restrictive lung disease

• Pulmonary hypertension

• End-stage organ disease (i.e. hepatic failure, renal failure)

• Arrhythmia

• Previous history of thoracic surgery