The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
Status:
Recruiting
Trial end date:
2023-11-30
Target enrollment:
Participant gender:
Summary
Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is
directly attributed to the progression or rupture of intracranial high-risk plaque in Asia.
Many studies mainly from Euro-American population with a focus on extracranial carotid plaque
have fully demonstrated the advantages of intensive statin therapy on stabilizing or
reversing plaque burden, reversing plaque composition presenting that lipid-rich necrotic
core (LRNC) is gradually replaced by fibrous tissue, and even reversing pattern of arterial
remodeling to reduce the occurrence of cerebrovascular events. Yet, direct evidence of the
effect of intensive statin therapy on intracranial atherosclerotic plaques is lacking and the
effect of statin intensity and duration on intracranial plaque burden and composition is
still unclear. High resolution magnetic resonance imaging (HRMRI) is a new and non-invasive
technique that enable to assess the morphologic characteristics of vascular wall and plaque
composition of intracranial artery. Based on above discussion, the investigators conduct this
study to further determine the effect of intensive statin in ischemic stroke with
intracranial atherosclerotic plaques.