The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy
Status:
Completed
Trial end date:
2020-08-06
Target enrollment:
Participant gender:
Summary
Injection of intraperitoneal bupivacaine revealed an analgesic effect whether injected alone
or in combination with other adjuvants, which increase duration of analgesia and decrease the
dose of administered bupivacaine thus minimizing its side effects e.g. Opioids,
Corticosteroids and Magnesium sulphate.
Neostigmine, a cholinesterase inhibitor that produces muscarinic receptor-mediated analgesia,
increased postoperative analgesia when combined with local anaesthetics. Peripheral afferent
nerve fibres contain muscarinic receptors, these could be a good target for pain suppression.