The Effect of Intravenous Erythromycin on Gastric Emptying in Non-fasted Patients Before Emergency Total Anesthesia

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study the investigators want to investigate the effect of a short intravenous infusion of Erythromycine on gastric emptying on patients considered "full stomac" and scheduled for Emergency operation. A gastroscopy will be done after intubation to controll the effect of the perfusion.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Geneva
• Treatments: Anesthetics; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin stearate

Criteria

Inclusion Criteria:

• Adults, age ≥18 years, male or female.

• American Society of Anaesthesiology [ASA] status I, II or III.

• Non-starving patients presenting for surgery.

• Patients able to read and understand the information sheet and to sign the consent form.

• If the patient is female and of childbearing potential, she must have a negative pregnancy test

Exclusion Criteria:

• A history of allergy or hypersensitivity to erythromycin or other macrolides.

• Concomitant use of terfenadine, astemizole, cisapride, pimozid, cyclosporine, clarithromycine.

• Patient with acute intermittent porphyria.

• Acute or subacute necrosis of the liver, acute or subacute hepatitis, acute liver trauma

• Acute renal failure, acute glomerulonephritis, nephritic syndrome, chronic renal failure with electrolyte disorders, uremia

• Exacerbated asthma, exacerbated chronic obstructive lung disease, acute pulmonary infection

• Coronary heart disease (unstable angina, MI within the last 6 months), decompensated cardiac insufficiency, aortic aneurysm

• Polyneuropathy (for instance, due to diabetes mellitus)

• Patients with oesophageal and pharyngeal disease (i.e. oesophageal varices, oesophageal and pharyngeal cancer, Zenker's diverticulum).

• Status after gastric surgery, gastric bypass surgery, Nissen operation

• Patients with life threatening illness or injury needing immediate surgery

• Patients with moderate to severe head trauma (GCS on admission <13)

• Psychological or psychiatric disorders.

• Dementia or inability to understand the study protocol.

• Women who are pregnant or are breast feeding.

• Patient scheduled for ileus surgery.