The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Patients were scheduled by following abdominal surgery under general anesthesia

• Aged 65 - 80 years

• ASA physical status Ⅱ-Ⅲ

Exclusion Criteria:

• Severe heart, pulmonary, hepatic and renal insufficiency

• History of neurological diseases (including Alzheimer's disease and stroke history)

• Psychological disorder, and drug or alcohol abuse

• History of anesthesia and surgery

• psychiatric illness

• Unwillingness to comply with the protocol or procedures

• Allergic to lidocaine

• Mini-Mental State Examination (MMSE) score<23 before surgery