The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the efficacy of intravenous lidocaine on THBS2, MMPs and VEGF-C in serum in cervical cancer patients undergoing radical hysterectomy under general anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General Hospital of Ningxia Medical University
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Patients were scheduled by following cervical cancer surgery under general anesthesia

• Aged 18-65 years

• ASA physical status Ⅱ-Ⅲ

Exclusion Criteria:

• Severe heart, pulmonary, hepatic and renal insufficiency

• History of neurological diseases

• Autoimmune disorders

• Antiarrhythmic drugs (amiodarone, verapamil, propafenone)

• Patients' decision to withdraw anytime from the study, and refusal to participate before surgery and at postoperative follow-up

• Allergy to one of the used medications

• Psychiatric illness, psychological disorder, and drug or alcohol abuse

• Unwillingness to comply with the protocol or procedures

• Preoperative treatment of chemotherapy, radiation, NSAID and hormonal therapy

• History of anesthesia and surgery in two weeks

• Coexisting other cancers and intraoperative presence of liver metastasis

• Perioperative treatment of blood transfusion