The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Status:
Completed
Trial end date:
2010-10-01
Target enrollment:
Participant gender:
Summary
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the
heart. Current treatments are designed at relieving this blockage as quickly as possible to
minimize damage to the heart muscle. However in restoring the supply of blood local damage
known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how
clot forming and clot dissolving pathways are affected during this process, and examine the
role of a natural inflammatory hormone, bradykinin. This will help the investigators to
understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new
treatments for heart attacks.