The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Edinburgh
• Collaborators: University of Aarhus; University of Oxford
• Treatments: Bradykinin; Bradykinin Receptor Antagonists; Icatibant; Kininogens

Criteria

Inclusion Criteria:

• healthy males between 18-65 years of ages

• non-smokers

Exclusion Criteria:

• any concurrent illness or chronic medical condition

• concurrent use of vasoactive medication

• smoking history