The Effect of L-Citrulline Malate on Ankle Brachial Index Among Patients With Coronary Heart Disease
Status:
Unknown status
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
In this randomized clinical trial before and after study we will assess the effect of
L-citrulline malate on brachial index in patients with coronary heart disease based on their
smoking history. Twenty patients with coronary heart disease with no history of diabetes or
other chronic diseases and with no history of myocardial infarction in the last 6 months will
participate in our trial.A written well-versed permission was attained from all patients. We
will measure the brachial index tow times once before giving L-Citrulline malate and the
other time after 2 weeks giving it.Patients receiving L-Citrulline malate as a 1 gram dry
powder agent twice a day, that should in use with 250 mg dilute water .The patients will
followed after 2 weeks by measuring brachial index which is our primary outcome measurement
in this trial.We assumed that the brachial index in both smoker and non-smoker group of
patients with coronary heart disease would change to normal or close to normal after giving 1
gram L-citrulline malate twice a day for 2 weeks.