The Effect of Late Na Current Blocker Mexiletine on Giant T-wave Electrical Alternans
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The electrocardiogram is one of the most basic tests for cardiovascular disease. T wave
alternans (TWA), which reflects abnormal ventricular repolarization, can easily trigger
ventricular tachycardia (VT) and ventricular fibrillation (VF), which are important warning
clues for sudden cardiac death (SCD). The late sodium current (INaL) is an important
component of the frequency-dependent regulation of cardiac repolarization, and various causes
of delayed repolarization can increase INaL. Our study on long QT syndrome (LQTS) found that
INaL abnormalities can lead to abnormal myocardial repolarization, producing a giant TWA that
triggers VT and VF. VT and VF, and INaL inhibition by the INaL blocker mexilate can terminate
this process. This suggests that pharmacological blockade of INaL may be a potential target
for the prevention of SCD by ameliorating the different causes of giant TWA and its
triggering ventricular arrhythmic events. In this study, we propose to randomize patients
with VT/VF triggered by giant TWA to conventional treatment and conventional treatment adds
mexiletine treatment to compare the effects of the two treatment regimens on giant TWA and
its triggered nonsustained VT, sustained VT, and VF; at the same time, we will compare the
effects of mexiletine on giant TWA and its triggered ventricular arrhythmias of various
etiologies by intra-group control before and after treatment. The safety and efficacy of the
treatment of TWA and its triggered ventricular arrhythmias are compared.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University