The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns

• Status: Completed
• Trial end date: 2020-06-11
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this research study is to compare the levels of free fatty acids and free bilirubin between two intravenous lipid emulsion products in premature newborns.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Bilirubin; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• premature newborns (<32 weeks gestation, stratified <28 weeks versus >28 weeks) <8 days of age

• receiving lipid infusions <1 g/kg/day at enrollment

• anticipated to be treated with 3 g/kg/day for a minimum of 48 hours.

Exclusion Criteria:

• patients with direct hyperbilirubinemia >1.5 mg/dl

• with suspected sepsis meeting Systemic inflammatory response syndrome (SIRS) criteria

• undergoing treatment with a continuous infusion of morphine

• with a continuous infusion of pressors (dopamine, dobutamine, epinephrine, etc.)

• positive blood cultures