The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Doppler, Biophysical Profile, CTG, Maternal Vital Signs in Women With Severe Preeclampsia

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

100 women with severe preeclanpsia received Magnesium sulfate 6 grams intravenous over 20 minutes as a loading dose. Resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio of the umbilical artery, uterine aryery and fetal middle cerebral artery before and repeated 20 minutes after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes . fetal breathing movements and fetal gross movements are counted within 20 minutes, before and after intravenous administration of 6 grams of magnesium sulphate (loading dose) over 20 minutes

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• Singleton pregnancy.

• Primigravida or Multigravida.

• Pregnant females ≥ 37 weeks of gestation.

• Diagnosed as severe preeclampsia by the following criteria:

• Sustained systolic blood pressure of ≥160 mmHg or a sustained diastolic blood pressure of ≥ 110 mmHg.

• Proteinuria measured as +1 or more by dipstick or 24 hours urine collection with proteinuria ≥ 0.3 grams.

• Oliguria or creatinine > 1.1 mg%.

• Laboratory findings characteristic of HELLP syndrome.

• Symptoms suggestive of severe preeclampsia ; severe headache, blurring of vision, epigastric pain.

Exclusion Criteria:

• Multifetal pregnancy.

• History of epilepsy.

• Patients with diabetes.

• Patients with renal disease.

• Fetuses with congenital anomalies.

• Patients receiving anticoagulants e.g. heparin (unfractionated or low molecular weight).

• Patients with severe IUGR.

• Patients with accidental hemorrhage.