The Effect of Local Anaesthetic Volume on Nerve Block Duration and Nerve Block Duration Variability

• Status: Completed
• Trial end date: 2017-03-20
• Target enrollment: 0
• Participant gender: All

Summary

The aim is to investigate the effect of perineural administration of a series of different volumes of local anaesthesia (ropivacaine 0.2%) on nerve block duration and the variability of the duration in the common peroneal nerve and the sciatic nerve in healthy volunteers.

The hypothesis is that nerve block duration is correlated to local anaesthetic volume, but only to a certain degree. After a sufficient volume a 'saturation level' will be reached, and nerve block duration will not increase further.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nordsjaellands Hospital
• Collaborator: Innovation Fund Denmark
• Treatments: Anesthetics; Anesthetics, Local; Ropivacaine

Criteria

Inclusion criteria

1. Male or female 18-64 years

2. American Society of Anesthesiologists Classification ≤ II

Exclusion criteria

1. Body Mass Index ≤ 18 or ≥ 30

2. Former surgery to the lower extremities

3. Peripheral nerve disease

4. Allergy to ropivacaine

5. Pregnancy or breastfeeding

6. Enrolment in other investigational drug studies or recent clinical trials that may interfere with this study

7. Habitual use of any kind of analgesic treatment

8. Anatomic abnormalities preventing successful US-guided peripheral nerve catheter insertion