The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery

• Status: Not yet recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Tranexamic acid (TXA) is a synthetic inhibitor of plasminogen lysine receptor that has used to reduce intra-operative bleeding in a number of clinical scenarios. Anecdotally, TXA has used by plastic surgeons to reduce post-operative bruising. To date, there is limited data to valid the benefits and to evaluate the side effects of TXA. The objective of this study is to evaluate the effect of local TXA on edema and ecchymosis in eyelid surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Consultants in Ophthalmic and Facial Plastics Surgery
• Treatments: Anesthetics; Anesthetics, Local; Tranexamic Acid

Criteria

Inclusion Criteria:

• Older than 18 years old

• Undergo bilateral upper/lower eyelid blepharoplasty, bilateral upper eyelid ptosis repair, or a combination of the above procedures

• Additional concurrent forehead/brow or upper/lower eyelids surgeries may be included if bilateral

Exclusion Criteria:

• Prior eyelid surgery

• Anticoagulant or antiplatelet use, including aspirin, within 7 days prior to surgery

• Patient who is currently pregnant or breast feeding

• Patient with color vision deficiency

• TXA allergy

• History of bleeding disorder

• History of clotting disorder

• History of seizure

• Have active nausea/vomiting/gastrointestinal symptoms

• Have active intracranial bleeding

• Have active periocular ecchymosis or edema prior to surgery