The Effect of Losartan in Bicuspid Aortic Valve Patients
Status:
Terminated
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
The specific aims of this study are to:
- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in
individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements
>40mm.
- Assess the effect on MMP levels during treatment with losartan, an angiotensin II
receptor blocking agent.
- In the setting of losartan therapy for one year, evaluate the response of MMP levels in
these patients, and clinical outcomes including effects on aortic growth rate