The Effect of Losartan on Emotional Processing in Healthy Volunteers

• Status: Completed
• Trial end date: 2017-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Treatments: Losartan

Criteria

Inclusion Criteria:

• willing and able to provide informed consent

• male or Female, aged 18-50

• body mass index (BMI) of 18-30 kg/m2

• fluent English skills

• non- or light-smoker (< 5 cigarettes a day)

Exclusion Criteria:

• Female participant who is pregnant or breast-feeding

• central nervous system (CNS) active medication during the last 6 weeks

• Current blood pressure/other heart medication (esp. aliskiren or beta blockers)

• Intravascular fluid depletion

• Past or present DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) axis-I diagnosis

• Alcohol or substance abuse

• First-degree family member with a history of a severe psychiatric disease

• Impaired liver or kidney function

• Lifetime history of epilepsy or other neurological disease, systemic infection, or clinically significant hepatic, cardiac, obstructive respiratory, renal, cerebrovascular, metabolic, endocrine or pulmonary disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study.

• Insufficient English skills

• participated in another study involving certain medication during last 6 weeks

• Contraindication to magnet resonance imaging (MRI) scanning (e.g. pacemaker)