The Effect of Low Dose Intra-operative Ketamine on Closed-loop Controlled General Anesthesia
Status:
Completed
Trial end date:
2018-10-17
Target enrollment:
Participant gender:
Summary
Closed-loop control of anesthesia involves using feedback from a measure of clinical effect
to continuously adjust drug infusion rates. As a result, anesthetic drugs are delivered at a
variable rate that is frequently personalized to each individual patient. The aim is to
provide greater stability at an optimal depth of anesthesia, reducing the occurrence of
under- or overdosing, with the goal of ultimately improving patient outcomes.
The purpose of this randomized, controlled equivalence trial is to compare controller
performance during closed-loop controlled induction and maintenance of total intravenous
anesthesia, using iControl system, with the addition of a low (analgesic) dose of ketamine
versus saline control.