The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients

• Status: Not yet recruiting
• Trial end date: 2023-12-10
• Target enrollment: 0
• Participant gender: Female

Summary

The most common side effect in cesarean section surgeries performed under spinal anesthesia is hypotension, which is seen in over 80% and can cause significant morbidity for the mother and fetus. This side effect results from the sympathetic blocking effect, which also causes bradycardia.

A combined approach is supported in the prevention and treatment of hypotension, which recommends adequate fluid support, low-dose spinal anesthesia, and appropriate vasopressor (such as ephedrine, and phenylephrine) and, if bradycardia develops, the use of atropine as a parasympatholytic agent.

In this study, we planned to investigate the possible benefits of preemptive administration of atropine, the dose of which is calculated in proportion to the patient's weight, as soon as a 10% decrease in heart rate is detected, in order to balance the sympathetic blockade due to spinal anesthesia in cesarean section operations.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Abant Izzet Baysal University
• Treatments: Atropine; Ephedrine

Criteria

Inclusion Criteria:

ASA Ι-ΙΙ, ages 18-40, weight 55-105 kg, height 150-175 cm, with an indication for elective cesarean section, and informed consent was obtained from the study. 60 pregnant patients at term planned to have cesarean delivery under spinal anesthesia were planned to be included.

Exclusion Criteria:

Those who do not require drug administration with fluid therapy, whose hemodynamic changes are within acceptable range, have systemic disease (Diabetes, COPD, Hypertension), have BMI>34, have a diagnosis of preeclampsia/eclampsia or multiple pregnancy, have pathology in the fetus, have hematological problems such as Rh incompatibility, Patients with hypersensitivity to local anesthetics and who are in a position to be a contraindication to regional anesthesia applications will not be accepted into the study