The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block

• Status: Completed
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate whether an optimized pre-treatment with intravenous magnesium enhances the speed of onset of a standard intubation dose of rocuronium.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Geneva
• Treatments: Magnesium Sulfate; Rocuronium

Criteria

Inclusion Criteria:

• American Society of Anaesthesiology (ASA) status I or II

• Adults, aged 18 years to 60 years

• Scheduled for elective surgery lasting longer than 120 min without need for continuous curarisation

Exclusion Criteria:

• A history of allergy or hypersensitivity to rocuronium

• Neuromuscular disease

• Preoperative medications known to influence neuromuscular function (for instance, certain antibiotics and anticonvulsants)

• Electrolyte abnormalities

• Hepatic or renal insufficiency

• Patients with a body mass index <19 or >28 kg m2

• Pregnant or breastfeeding women

• Expected difficult intubation or mask ventilation