The Effect of Melatonin on Nocturnal Enuresis

• Status: Unknown status
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Aim: To investigate the effect of melatonin in bedwetting.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Monosymptomatic nocturnal enuresis

• Age 6-14 years

• Clinical examination normal

• ≥ 3 wet nights / week due to either nocturnal polyuria with normal bladder size or reduced functional bladder capacity with normal urine output

Exclusion Criteria:

• Constipation (by ROME III criteria)

• Day incontinence

• Overactive bladder (ICCS 2008 classification of symptoms)

• Current or past history of clinical or laboratory findings that can be related to diseases or - conditions (eg pregnancy) likely to change the parameters examined, especially diseases of the kidney and urinary tract, liver or endocrine disorder.

• Clinical signs of urinary tract infection

• Hypertension, blood pressure assessed by ambulatory measurement with blood pressure cuff

• Set treatment with one or more drugs