The Effect of Metformin on Fecundability in an ART(Assisted Reproductive Technology) Setting - the Correlation to Uterine Flows

• Status: Unknown status
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The basis for obesity's impact on reproduction is not well characterised and there is a controversy whether the key organ influenced by it are the ovaries or the uterus.

Insulin sensitizers ameliorate insulin resistance in obese patients. This study seeks to determine if Metformin helps to increase fecundability by affecting the uterus in women undergoing ART. As a surrogate marker- flows in the uterus will be tested during the treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Baruch Padeh Medical Center, Poriya
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Age: from 18-40 years old.

• BMI > 30

• Infertile women undergoing frozen-thawed embryo transfer in an ART setting

• Women with at least one Top graded embryo

• Normal uterine Doppler indices at time of recruitment.

Exclusion Criteria:

• Diabetes mellitus - uncontrolled.

• Hyperprolactinemia- uncontrolled.

• Hypothyroidism- uncontrolled.

• women who are already treated with Metformin

• women with endometrial factor as the cause for infertility