The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine

• Status: Terminated
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is the evaluation of effect of metformin on obesity and metabolic disturbance in patients taking clozapine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborator: Daewoong Pharmaceutical Co. LTD.
• Treatments: Clozapine; Metformin

Criteria

Inclusion Criteria:

• Age: 18 ~ 65

• Patient with schizophrenia according to DSM-IV criteria

• Patient have signed on the informed consent, and well understood the objective and procedure of this study.

• Patient taking clozapine 3months or more

• Patient increased in weight more than 10 % of that of before antipsychotics use

Exclusion Criteria:

• Patient taking other antipsychotics with clozapine

• Patient in treatment of diabetes

• Patient in treatment of dyslipidemia

• Allergy or hypersensitivity to metformin

• Pregnant or breast-feeding female patient.

• Patient with severe medical condition