The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients

• Status: Withdrawn
• Trial end date: 2018-03-21
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of the study is to test the effects of metoprolol on anaesthesia and the need for perioperative analgesics in patients undergoing breast surgery. With 12 months follow-up the incidence of pain and life satisfaction will be evaluated.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kuopio University Hospital
• Treatments: Analgesics; Metoprolol

Criteria

Inclusion Criteria:

• Elective breast surgery due to breast cancer

• Voluntary

• BMI ≥ 18 and ≤ 35 kg/m2

• ASA 1-3

• No regular use of beta-blockers or during the last 72 hours

• No contraindications to beta-blockers

Exclusion Criteria:

• Pregnancy or breast feeding

• AV-block, degree II or III

• Untreated cardiac insufficiency

• Sinus bradycardia, heart rate < 45 / min or symptoms

• Sick sinus syndrome

• Cardiogenic shock

• Severe peripheral vascular disorder

• Systolic blood pressure < 100 mmHg

• Long PQ-time, > 0,24 seconds

• Known hypersensitivity to beta-blockers or the ingredients of the drug