The Effect of Midazolam on Dexamethasone-induced Perineal Pruritus
Status:
Recruiting
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
Dexamethasone is commonly used in clinical practice.However, intravenous dexamethasone sodium
phosphate may cause perineal discomfort.With the popularization of comfortable medical
technology, patients have higher and higher requirements for comfortable medical
treatment.Perineal pruritus caused by intravenous dexamethasone sodium phosphate may cause
adverse physiological and psychological effects on patients and increase the incidence of
unpleasant experiences during anesthesia.Therefore, it is very important to find a practical
and effective method of inhibition.Midazolam is a water-soluble benzodiazepine commonly used
in clinical practice, which has been proved to effectively inhibit the itching caused , while
its effect on the itching caused by dexamethasone has not been reported.By observing the
effect of pre-injection midazolam on the perineal itching caused by dexamethasone sodium
phosphate, this experiment intends to preliminarily explore its possible mechanism .