The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a pilot study investigating the effect of an antioxidant, N-Acetyl-L-Cysteine (NAC), on inflammation and oxidative stress in sarcoidosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Jewish Health
• Collaborator: American Thoracic Society
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Biopsy proven sarcoidosis.

• Pulmonary parenchymal involvement with a Scadding chest x-ray stage II, III or IV.

• Abnormal spirometry and/or DLCO (< 80% of predicted).

• Consenting adults : Age 18 years and above

Exclusion Criteria:

• Positive lung washing or biopsy cultures for fungi or mycobacterial disease;

• Presence of other co-morbid conditions that may affect the patient's outcome.

• Patient inability to undergo venipuncture and BAL procedures.

• Current use of tobacco (smoking or otherwise) in the past 6 months

• Treatment with immunosuppressive therapy within the past 6 months.

• On oral anti-oxidant supplements.

• Active peptic ulcer disease.