The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major

• Status: Completed
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study duration

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Acetylcysteine; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Thalassemia major children on regular blood transfusion and iron chelation therapy

Exclusion Criteria:

• Renal or hepatic impairments

• Complicated thalassemia major

• Non adherence to therapy or follow up visits

• Change in the iron chelation dose within 3 months before enrollment or during study period