The Effect of N2O on Chronic Neuropathic Pain Patients

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Important pharmacological agents for treatment of chronic neuropathic pain such as ketamine block NMDA receptors. Nitrous oxide, an inhalant agent used extensively In anesthesia, also have antagonist property of NMDA receptors. The investigators hypothesize that prolonged treatment with N2O can alleviate chronic neuropathic pain of different causes (e.g. diabetic neuropathy, post herpetic neuralgia etc.).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Criteria

Inclusion Criteria:

• men and women at the age 18-65

• patient that suffer from chronic neuropathic pain

• VAS>40

• DN4 score >4

• takes pain medication on a regular basis

• Didn't get epidural injection for the pas month

• signed an informed consent form

Exclusion Criteria:

• patients that suffer from chronic lung disease.

• patients with cancer

• patients with heart disease

• pregnant and lactate woman

• patients that suffer from depression