The Effect of Nebivolol on Insulin Sensitivity

• Status: Completed
• Trial end date: 2009-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity, 24 hour blood pressure profile, and tolerability of nebivolol plus a thiazide-like diuretic versus atenolol plus a thiazide-like diuretic.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Imperial College London
• Collaborator: Foundation for Circulatory Health
• Treatments: Atenolol; Insulin; Nebivolol

Criteria

Inclusion Criteria:

• Males or females aged 18 or above

• Blood pressure that meets any of the three following criteria:

• BP should be <140/85 mmHg on a maximum of two anti-hypertensive drugs

Exclusion Criteria:

• contraindications to beta-blockade

• contraindications to thiazide use

• if there was a history of asthma, diabetes, heart failure, bradycardia, atrial fibrillation, AV conduction disturbances

• concurrent treatment with verapamil & dilitiazem

• childbearing women

• compelling indication for treatment with a beta blocker

• any condition that will interfere with the treatment or the patient's ability to complete the study