The Effect of Nimodipine on the Postoperative Cognitive Dysfunction

• Status: Terminated
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The calcium channel blocker nimodipine dilates cerebral blood vessels and can pass through the blood-brain barrier, providing neuroprotective effects by selectively improving cerebral blood flow and inhibiting neuronal necrosis and apoptosis. Nimodipine significantly inhibited the production of tumor necrosis factor TNF-α and interleukin IL-1β, and also of nitric oxide and prostaglandin E2 from lipopolysaccharide-stimulated microglia. Abnormal cytokine networks are important in the development of nerve cell damage that leads to cognitive impairment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Hradec Kralove
• Treatments: Nimodipine

Criteria

Inclusion Criteria:

• Glascow coma scale GCS 15 preoperatively

• American Society of Anesthesiologists ASA risk I - III

• planned brain surgery

• duration of procedure up to 4 hours.

Exclusion Criteria:

• blood pressure below 130/80 torr preoperatively

• previous vascular surgery

• concomitant use of antiepileptic drugs, rifampicin

• allergy to nimodipine

• known liver cirrhosis