The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department

• Status: Unknown status
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the anti-emetic effect of oral ondansetron. For this evaluation, the investigators will perform a multi-center, double-blind, placebo-controled, randomized study. The investigators assumption is that oral ondansetron prior to intramuscular ketamine will reduce the occurrence of ketamine-induced vomiting.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Hospital
• Collaborators: Asan Medical Center; Myongji Hospital
• Treatments: Ketamine; Ondansetron

Criteria

Inclusion Criteria:

• children under 18 years of age

• children who are planned to admit ketamine intramuscular injection

• children with ASA classification class I or II

Exclusion Criteria:

• don't want to enroll to study

• children with condition of contraindication of ketamine (IICP, IIOP, psychosis, brain tumor, thyroid disease, porphyria)

• children with condition of contraindication of ondansetron (hypersensitivity to 5-HT3 antagonist, Long QT syndrome, severe liver failure, obstructive ileus)

• children under 3 months of age

• children whose weight are over 30 kg

• children managed by other drug with ketamine