The Effect of Oral Antibiotics on Synovial Fluid and Differential for the Diagnosis of Infection

• Status: Withdrawn
• Trial end date: 2019-11-05
• Target enrollment: 0
• Participant gender: All

Summary

Periprosthetic joint infection following total hip or knee arthroplasty is a rare but potentially devastating complication. Accurate diagnosis of these infections remains one of the most challenging undertakings in orthopaedics. Multiple studies have shown the high diagnostic accuracy of synovial fluid white blood cell count (WBC) and neutrophil percentage (%PMNs) in detecting PJI. This study's goal is to evaluate how antibiotics affect those two important diagnostic measures.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rush University Medical Center
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

1. Patient>18 years old.

2. Patient with a prosthetic hip or knee in place.

3. Patient with PJI of the hip or knee based on MSIS criteria3(Table 1).

4. Patient off of antibiotics for a minimum of two weeks prior to preoperative joint aspiration.

5. Patient with a culture-positive preoperative joint aspiration

Exclusion Criteria:

1. Inadequate preoperative or intraoperative synovial fluid sample to perform synovial fluid WBC, %PMN and aerobic/anaerobic cultures.

2. Pregnant women.