The Effect of Oral Pregabalin on Epidural-induced Shivering and Epidural Characteristics

• Status: Completed
• Trial end date: 2018-11-15
• Target enrollment: 0
• Participant gender: Female

Summary

• Background: The previous reports tried to reduce shivering and improve neuroaxial anesthesia characteristics by the systemic use of different drugs. This study was directed to evaluate the effect of pregabalin premedication on both shivering and epidural outcome data following single shot loading.

• Patients and Methods: Eighty patients, ASA grade I and II, undergoing surgeries under epidural anesthesia were studied. The patients were divided into two groups: Pregabalin group and Control group in which the patients received 150 mg of pregabalin and placebo capsules respectively sixty minutes prior to surgery. Following epidural loading, the onset and degree of shivering were compared between the two groups. Also, the epidural outcome including onset, level and duration were traced and compared. The perioperative hemodynamics, sedation scores, patient satisfaction and side effects were followed up and registered.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

• adults female patients (20 - 60 years old)

• with an American society of Anesthegiologists physical status (ASA) I-II

• undergoing gynecological surgery

Exclusion Criteria:

• ASA class was more than II,

• anticipated difficult epidural insertion

• any contraindication to epidural anesthesia, if any patient developed wet or bloody tab, or the patients were under psychotropic or antiepileptic therapy.