The Effect of Oxygen Given to Patients in the Postoperative Period on Nausea and Vomiting
Status:
Not yet recruiting
Trial end date:
2023-05-03
Target enrollment:
Participant gender:
Summary
Carbon dioxide which is insufflated to inflate the abdominal area is absorbed from the
peritoneal area and it increases endogenous catecholamines, which may consequently increase
nausea and vomiting. In the literature, it is indicated that oxygen application which is one
of the applications aiming to prevent nausea and vomiting is a cheap method with fewer side
effects in the prevention of postoperative nausea and vomiting.
In the literature, studies on the prevention of nausea and vomiting by oxygen application in
different surgical interventions have not arrived at a consensus regarding surgery type and
oxygen amounts. There are studies evaluating 80% and 30% oxygen amounts in removing
postoperative nausea and vomiting. Taking these conditions into consideration; the study has
been planned for the purpose of examining the impact of giving 80% and 60% oxygen to patients
to whom laparoscopic cholecystectomy is applied on postoperative nausea and vomiting in the
postoperative period.
The study has been planned as a randomized controlled study for the purpose of determining
the impact of giving oxygen (80% to the group A, 60% to the group B and control group C) to
patients who apply to the general surgery service to undergo a laparoscopic cholecystectomy
on postoperative nausea and vomiting in the postoperative period. The patients in the study
will have the same standard anesthesia protocol and hospital routine. The study will be
terminated once a total of 111 patients have been reached. In the study randomization, the
patients will be assigned to the sample group according to weeks as they may influence each
other. Data will be collected using Patient Introductory Information Form, which evaluates
patients' socio-demographic characteristics, as well as Perioperative Period Patient
Follow-Up Form and Postoperative Period Nausea-Vomiting Frequency and Severity Evaluation
Form. Statistical analysis of the data to be acquired as a result of the study will be
performed in the computer environment. The results to be obtained will be evaluated at p<0,05
significance level.
It is expected that the study results will provide an alternative method, which will be used
in preventing the possible side effects of postoperative nausea and vomiting in patients who
undergo a laparoscopic cholecystectomy. Thus, the study results may make scientific and
socio-economic contributions.
Phase:
Phase 3
Details
Lead Sponsor:
Selcuk University
Collaborator:
The Scientific and Technological Research Council of Turkey