The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG), in Cycles Induced by Letrozole or Clomiphene Citrate

• Status: Completed
• Trial end date: 2007-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

The specific aims of this study were to assess whether letrozole as an aromatase inhibitor plus hCG or OT alone, or in combination compared with CC, improves ovarian response.Ethical design of this study is based on the ethical guidelines of the Iranian Medical and Health Ministry which is accepted by Tabriz medical university ethical committee .

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tabriz University
• Treatments: Chorionic Gonadotropin; Citric Acid; Clomiphene; Enclomiphene; Letrozole; Oxytocin; Zuclomiphene

Criteria

Inclusion Criteria:

• infertile women who had chronic anovulation

• classical PCOS with CC+hCG failure

• age <40 y

• had patent tubes on hysterosalpingography

• no other pelvic pathology

• participated in this study

Exclusion Criteria:

• hypersensitivity to any oxytocic medications

• history of cardiovascular disease

• took anti-hypertensive medications were excluded.

• women with blood pressure less than 90/60 mmHg

• abnormal spermogram

• anxiety

• excess prolactin levels

• other causes of infertility were excluded